The role of neural inflammation in asthma and chronic obstructive pulmonary disease

被引：32

作者：

Joos, GF ^{[1
]}

De Swert, KO ^{[1
]}

Schelfhout, V ^{[1
]}

Pauwels, RA ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Resp Dis, B-9000 Ghent, Belgium

来源：

NEUROENDOCRINE AND NEURAL REGULATION OF AUTOIMMUNE AND INFLAMMATORY DISEASE: MOLECULAR, SYSTEMS, AND CLINICAL INSIGHTS | 2003年 / 992卷

关键词：

substance P; neurokinin A; tachykinins; asthma; neurogenic airway inflammation; tachykinin receptor antagonists;

D O I：

10.1111/j.1749-6632.2003.tb03152.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tachykinins substance P and neurokinin A are found within airway nerves and immune cells. They have various effects on the airways that can contribute to the changes observed in asthma and chronic obstructive pulmonary disease. Both tachykinin NK1 and NK2 receptors have been involved in the bronchoconstriction and the proinflammatory changes induced by substance P and neurokinin A. Tachykinin NK1 and NK2 receptor antagonists have activity in various animal models of allergic asthma and chronic bronchitis. It is suggested that dual NK1/NK2 and triple NK1/NK2/NK3 tachykinin receptor antagonists have potential in the treatment of obstructive airway diseases.

引用

收藏

页码：218 / 230

页数：13

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