Antioxidant therapy and cardiovascular disorders

被引：6

作者：

Chrysselis, MC ^{[1
]}

Rekka, EA ^{[1
]}

Kourounakis, PN ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54006, Greece

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2001年 / 11卷 / 01期

关键词：

antioxidants; arrhythmia; atheromatosis; cardiovascular disease; free radicals; ischaemia;

D O I：

10.1517/13543776.11.1.33

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cardiovascular diseases constitute the major cause of death in Western societies. Atherosclerosis is the most common disorder and the pathogenesis of this condition is related to oxidative modifications, leading to the induction of inflammatory mechanisms and finally to the formation of atheromatic plaques. Furthermore, radical mediated destruction of sarcoplasmic membranes is involved in arrhythmias and myocardial ischaemia. - reoxgenation. Several recent studies, considering the participation of free radicals in the development of heart disorders, propose thf use of antioxidant compounds or preparations in order to prevent the progression of the disease. This article focuses on the patents dated from 1998 through to the fist quarter of 2000, which are related to the therapeutic approaches to the major cardiovascular diseases.

引用

页码：33 / 43

页数：11

共 69 条

[11]

CTR NAT RECHERCHE SC, 1999, Patent No. 9952911

[12]

DENINNO MP, 2000, Patent No. 0017165

[13]

DRAKE TA, 1991, AM J PATHOL, V138, P601

[14]

DUKE U MED, 1998, Patent No. 9834955

[15]

EASTMAN CHEM CO, 2000, Patent No. 6020383

[16]

Eberhardt RT, 2000, CONTEMP CARDIOL, P273

[17] REGULATION OF ENDOTHELIAL-CELL TISSUE FACTOR EXPRESSION BY MINIMALLY OXIDIZED LDL AND LIPOPOLYSACCHARIDE [J].

FEI, HH ;

BERLINER, JA ;

PARHAMI, F ;

DRAKE, TA .

ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (11) :1711-1717

[18] AN ANCIENT, HIGHLY CONSERVED FAMILY OF CYSTEINE-RICH PROTEIN DOMAINS REVEALED BY CLONING TYPE-I AND TYPE-II MURINE MACROPHAGE SCAVENGER RECEPTORS [J].

FREEMAN, M ;

ASHKENAS, J ;

REES, DJG ;

KINGSLEY, DM ;

COPELAND, NG ;

JENKINS, NA ;

KRIEGER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8810-8814

[19] THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].

FURCHGOTT, RF ;

ZAWADZKI, JV .

NATURE, 1980, 288 (5789) :373-376

[20] MECHANISMS LEADING TO MYOCARDIAL-INFARCTION - INSIGHTS FROM STUDIES OF VASCULAR BIOLOGY [J].

FUSTER, V .

CIRCULATION, 1994, 90 (04) :2126-2146

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