Pyridine Activation via Copper(I)-Catalyzed Annulation toward indolizines

被引：187

作者：

Barluenga, Jose ^{[1
]}

Lonzi, Giacomo ^{[1
]}

Riesgo, Lorena ^{[1
]}

Lopez, Luis A. ^{[1
]}

Tomas, Miguel ^{[1
]}

机构：

[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, Unidad Asociada CSIC, E-33006 Oviedo, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 38期

关键词：

CATALYZED CYCLOISOMERIZATION; VINYLOGOUS REACTIVITY; EFFICIENT SYNTHESIS; HETEROCYCLES; DERIVATIVES; INSERTIONS; QUINOLINES; LIGANDS; ROUTE;

D O I：

10.1021/ja106751t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The copper(I)-catalyzed regioselective [3 + 2] cyclization of pyridines toward alkenyldiazoacetates leading to functionalized indolizine derivatives is reported. A broad range of pyridine derivatives (including quinoline and isoquinoline) is compatible with this cyclization reaction. The process represents the first successful example of metal-catalyzed cyclization of a pi-deficient heterocyclic system with alkenyldiazo compounds.

引用

页码：13200 / 13202

页数：3

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