Low temperature organocopper-mediated two-component cross coupling/cycloisomerization approach toward N-fused heterocycles

被引：89

作者：

Chernyak, Dmitri ^{[1
]}

Gadamsetty, Surendra Babu ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 11期

关键词：

D O I：

10.1021/ol8008705

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce Mused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an S(N)2' substitution followed by a subsequent cycloisomerization step.

引用

页码：2307 / 2310

页数：4

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