Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

被引：5

作者：

Bevins, RA

Delzer, TA

Bardo, MT

机构：

[1] Department of Psychology, Kastle Hall, University of Kentucky, Lexington

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1996年 / 53卷 / 03期

关键词：

7-hydroxy-N; N-di-n-propyl-2-aminotetralin; 7-OH-DPAT; saccharin taste aversion; dopamine; D-3; receptor; D-2; reward; amphetamine; cocaine; sigma receptor;

D O I：

10.1016/0091-3057(95)02071-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D-3 agonist (+/-)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

引用

页码：695 / 699

页数：5

共 31 条

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