Perisomatic inhibition

被引:518
作者
Freund, Tamas F. [1 ]
Katona, Istvan [1 ]
机构
[1] Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary
基金
匈牙利科学研究基金会;
关键词
D O I
10.1016/j.neuron.2007.09.012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.
引用
收藏
页码:33 / 42
页数:10
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