Antimicrobial prenylated dihydrochalcones from Eriosema glomerata

被引：31

作者：

Awouafack, Maurice D. ^{[2
]}

Kouam, Simeon F. ^{[1
,3
]}

Hussain, Hidayat ^{[3
]}

Ngamga, Dieudonne ^{[2
]}

Tane, Pierre ^{[2
]}

Schulz, Barbara ^{[4
]}

Green, Ivan R. ^{[5
]}

Krohn, Karsten ^{[3
]}

机构：

[1] Univ Yaounde 1, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon

[2] Univ Dschang, Dept Chem, Dschang, Cameroon

[3] Univ Gesamthsch Paderborn, Dept Chem, Paderborn, Germany

[4] Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, Braunschweig, Germany

[5] Univ Western Cape, Dept Chem, ZA-7535 Bellville, South Africa

来源：

PLANTA MEDICA | 2008年 / 74卷 / 01期

关键词：

Eriosema glomerata; Fabaceae; dihydrochalcone; antimicrobial; Erioschalcone A; Erioschalcone;

D O I：

10.1055/s-2007-993782

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new natural dihydrochalcones exhibiting antimicrobial properties together with six known compounds were isolated from the Cameroonian medicinal plant Eriosema glomerata. The structures of the new dihydrochalcones were elucidated as 2',4'-dihydroxy-4-methoxy-3'-(gamma,gamma-dimethylallyl)dihydrochalcone and 2',4'-dihydroxy-3-(gamma,gamma-dimethylallyl)dihydrochalcone by detailed spectroscopic analysis. The two new dihydrochalcones, named erioschalcones A (1) and B (2), demonstrated significant inhibitory activity against the microbial strains Bacillus megaterium, Escherichia coli, Chlorella fusca and Microbotryum violaceum.

引用

页码：50 / 54

页数：5

共 27 条

[1]

ADITYACHAUDHURY N, 1975, SYNTHESIS TETRAHYDRO, P179

[2] Cytotoxic chalcones of flavonoids from the leaves of Muntingia calabura [J].

Chen, JJ ;

Lee, HH ;

Duh, CY ;

Chen, IS .

PLANTA MEDICA, 2005, 71 (10) :970-973

[3] Antioxidant properties of neohesperidin dihydrochalcone: Inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death [J].

Choi, Je-Min ;

Yoon, Byoung-Seok ;

Lee, Sang-Kyou ;

Hwang, Jae-Kwan ;

Ryang, Ryung .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (02) :324-330

[4] Minor pyrano-isoflavones from Eriosema kraussianum:: activity-, structure-, and chemical reaction studies [J].

Drewes, SE ;

Horn, MM ;

Khan, F ;

Munro, OQ ;

Dhlamini, JTB ;

Rakuambo, C ;

Meyer, JM .

PHYTOCHEMISTRY, 2004, 65 (13) :1955-1961

[5] Pyrano-isoflavones with erectile-dysfunction activity from Eriosema kraussianum [J].

Drewes, SE ;

Horn, MM ;

Munro, OQ ;

Dhlamini, JTB ;

Meyer, JJM ;

Rakuambo, NC .

PHYTOCHEMISTRY, 2002, 59 (07) :739-747

[6] Antimicrobial and antioxidant flavonoids from the root wood of Bolusanthus speciosus [J].

Erasto, P ;

Bojase-Moleta, G ;

Majinda, RRT .

PHYTOCHEMISTRY, 2004, 65 (07) :875-880

[7] Chalconoid and stilbenoid glycosides from Guibourtia tessmanii [J].

Fuendjiep, V ;

Wandji, J ;

Tillequin, F ;

Mulholland, DA ;

Budzikiewicz, H ;

Fomum, ZT ;

Nyemba, AM ;

Koch, M .

PHYTOCHEMISTRY, 2002, 60 (08) :803-806

[8] Fungi from marine sponges:: diversity, biological activity and secondary metabolites [J].

Höller, U ;

Wright, AD ;

Matthée, GF ;

Konig, GM ;

Draeger, S ;

Aust, HJ ;

Schulz, B .

MYCOLOGICAL RESEARCH, 2000, 104 :1354-1365

[9] NEW DIHYDROCHALCONES AND FLAVANONES FROM UVARIA-ANGOLENSIS [J].

HUFFORD, CD ;

OGUNTIMEIN, BO .

JOURNAL OF NATURAL PRODUCTS, 1982, 45 (03) :337-342

[10] Phenolic components of Empetrum nigrum extract and the crystal structure of one of them [J].

Krasnov, EA ;

Ermilova, EV ;

Kadyrova, TV ;

Raldugin, VA ;

Bagryanskaya, IY ;

Gatilov, YV ;

Druganov, AG ;

Semenov, AA ;

Tolstikov, GA .

CHEMISTRY OF NATURAL COMPOUNDS, 2000, 36 (05) :493-496

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