Minor pyrano-isoflavones from Eriosema kraussianum:: activity-, structure-, and chemical reaction studies

被引：11

作者：

Drewes, SE

Horn, MM

Khan, F

Munro, OQ

Dhlamini, JTB

Rakuambo, C

Meyer, JM

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys Sci Chem, ZA-3209 Pietermaritzburg, South Africa

[2] Univ Pretoria, Dept Bot, ZA-0002 Pretoria, South Africa

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

Eriosema kraussianum; pyrano-isoflavones; cyclization; smooth muscle contraction; X-ray;

D O I：

10.1016/j.phytochem.2004.04.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The isolation and identification of two minor pyrano-isoflavones from Eriosema kraussianum is described. New studies on the original pyrano-isoflavones shows that: (i) kraussianone 2 (a major compound in the plant) can be cyclised under acid conditions, (ii) kraussianones 3 and 5 cause contraction (not relaxation as anticipated) of corpus cavernosum tissue and (iii) the structures proposed previously for 4 and 5 are confirmed by the data obtained from an X-ray study of 5. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1955 / 1961

页数：7

共 9 条

[1] Recent findings on natural products with erectile-dysfunction activity [J].