;Cells secrete various membrane-enclosed microvesicles from their cell surface (shedding microvesicles) and from internal, endosome-derived membranes (exosomes). Intriguingly, these vesicles have many characteristics in common with enveloped viruses, including biophysical properties, biogenesis, and uptake by cells. Recent discoveries describing the microvesicle-mediated intercellular transfer of functional cellular proteins, RNAs, and mRNAs have revealed additional similarities between viruses and cellular microvesicles. Apparent differences include the complexity of viral entry, temporally regulated viral expression, and self-replication proceeding to infection of new cells. Interestingly, many virally infected cells secrete microvesicles that differ in content from their virion counterparts but may contain various viral proteins and RNAs. For the most part, these particles have not been analyzed for their content or functions during viral infection. However, early studies of microvesicles (L-particles) secreted from herpes simplex virus-infected cells provided the first evidence of microvesicle-mediated intercellular communication. In the case of Epstein-Barr virus, recent evidence suggests that this tumorigenic herpesvirus also utilizes exosomes as a mechanism of cell-to-cell communication through the transfer of signaling competent proteins and functional microRNAs to uninfected cells. This review focuses on aspects of the biology of microvesicles with an emphasis on their potential contributions to viral infection and pathogenesis.
机构:
Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Gastaminza, Pablo
;
Dryden, Kelly A.
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机构:
Univ Virginia, Sch Med, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Dryden, Kelly A.
;
Boyd, Bryan
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机构:
Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Boyd, Bryan
;
Wood, Malcolm R.
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Scripps Res Inst, TSRI Core Microscopy, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Wood, Malcolm R.
;
Law, Mansun
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Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Law, Mansun
;
Yeager, Mark
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机构:
Univ Virginia, Sch Med, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA
Scripps Clin, Div Cardiovasc Dis, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Yeager, Mark
;
Chisari, Francis V.
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机构:
Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
机构:
Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Gastaminza, Pablo
;
Dryden, Kelly A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Sch Med, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Dryden, Kelly A.
;
Boyd, Bryan
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Boyd, Bryan
;
Wood, Malcolm R.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, TSRI Core Microscopy, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Wood, Malcolm R.
;
Law, Mansun
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h-index: 0
机构:
Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Law, Mansun
;
Yeager, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Sch Med, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA
Scripps Clin, Div Cardiovasc Dis, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Yeager, Mark
;
Chisari, Francis V.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA