Microvesicles and Viral Infection

被引:313
作者
Meckes, David G., Jr. [1 ]
Raab-Traub, Nancy [1 ]
机构
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
关键词
CELL-DERIVED EXOSOMES; LATENT MEMBRANE PROTEIN-1; STRUCTURES L-PARTICLES; MULTIVESICULAR BODIES; T-CELLS; HUMAN CYTOMEGALOVIRUS; ACTIVATED PLATELETS; PROTEOMIC ANALYSIS; APOPTOTIC BODIES; EXTRACELLULAR VESICLES;
D O I
10.1128/JVI.05853-11
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
;Cells secrete various membrane-enclosed microvesicles from their cell surface (shedding microvesicles) and from internal, endosome-derived membranes (exosomes). Intriguingly, these vesicles have many characteristics in common with enveloped viruses, including biophysical properties, biogenesis, and uptake by cells. Recent discoveries describing the microvesicle-mediated intercellular transfer of functional cellular proteins, RNAs, and mRNAs have revealed additional similarities between viruses and cellular microvesicles. Apparent differences include the complexity of viral entry, temporally regulated viral expression, and self-replication proceeding to infection of new cells. Interestingly, many virally infected cells secrete microvesicles that differ in content from their virion counterparts but may contain various viral proteins and RNAs. For the most part, these particles have not been analyzed for their content or functions during viral infection. However, early studies of microvesicles (L-particles) secreted from herpes simplex virus-infected cells provided the first evidence of microvesicle-mediated intercellular communication. In the case of Epstein-Barr virus, recent evidence suggests that this tumorigenic herpesvirus also utilizes exosomes as a mechanism of cell-to-cell communication through the transfer of signaling competent proteins and functional microRNAs to uninfected cells. This review focuses on aspects of the biology of microvesicles with an emphasis on their potential contributions to viral infection and pathogenesis.
引用
收藏
页码:12844 / 12854
页数:11
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