The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas

被引：45

作者：

Bredel, M ^{[1
]}

Pollak, IF

机构：

[1] Univ Pittsburgh, Sch Med, Dept Neurosurg, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Inst Canc, Brain Tumor Ctr, Pittsburgh, PA 15261 USA

来源：

BRAIN RESEARCH REVIEWS | 1999年 / 29卷 / 2-3期

关键词：

apoptosis; astrocytoma; cell proliferation; farnesyltransferase; geranylgeranyltransferase; glioblastoma multiforme; glioma growth; growth factor; growth inhibition; high-grade glioma; p21-Ras overactivation; mutation; signal transduction;

D O I：

10.1016/S0165-0173(98)00057-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deregulated p21-Ras function, as a result of mutation, overexpression or growth factor-induced overactivation, contributes to at least 30% of human cancer. This article reviews the potential role of the p21-Ras family of GTPases in the regulation of growth of high-grade gliomas and describes how targeting this oncoprotein clinically may provide a novel strategy to counteract glioma proliferation. The application of strategies directed at selectively opposing the deregulated signal transduction pathway of high-grade gliomas may be of potential therapeutic benefit and may offer a whole new arsenal of antineoplastic agents to be included in the multimodal treatment of these challenging neoplasms. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：232 / 249

页数：18

共 258 条

[1] GROWTH-FACTORS AND CANCER
AARONSON, SA
[J]. SCIENCE, 1991, 254 (5035) : 1146 - 1153
[2] AARONSON SA, 1993, ADV EXP MED BIOL, V348, P7
[3] ADLER V, 1992, J BIOL CHEM, V267, P17001
[4] Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120(GAP) and neurofibromin
Ahmadian, MR
Wiesmuller, L
Lautwein, A
Bischoff, FR
Wittinghofer, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (27) : 16409 - 16415
[5] IDENTIFICATION OF THE SITES IN MAP KINASE KINASE-1 PHOSPHORYLATED BY P74(RAF-1)
ALESSI, DR
SAITO, Y
CAMPBELL, DG
COHEN, P
SITHANANDAM, G
RAPP, U
ASHWORTH, A
MARSHALL, CJ
COWLEY, S
[J]. EMBO JOURNAL, 1994, 13 (07) : 1610 - 1619
[6] BINDING OF THE RAS ACTIVATOR SON OF SEVENLESS TO INSULIN-RECEPTOR SUBSTRATE-1 SIGNALING COMPLEXES
BALTENSPERGER, K
KOZMA, LM
CHERNIACK, AD
KLARLUND, JK
CHAWLA, A
BANERJEE, U
CZECH, MP
[J]. SCIENCE, 1993, 260 (5116) : 1950 - 1952
[7] ECONOMIC-ASPECTS OF TROPICAL DEFORESTATION IN SOUTHEAST-ASIA
BARBIER, EB
[J]. GLOBAL ECOLOGY AND BIOGEOGRAPHY, 1993, 3 (4-6): : 215 - 234
[8] Barnard D, 1995, ONCOGENE, V10, P1283
[9] BIGNER SH, 1988, CANCER RES, V48, P405
[10] SIGNAL-TRANSDUCTION VIA THE MAP KINASES - PROCEED AT YOUR OWN RSK
BLENIS, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) : 5889 - 5892

← 1 2 3 4 5 6 7 8 9 10 →