The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas

被引：45

作者：

Bredel, M ^{[1
]}

Pollak, IF

机构：

[1] Univ Pittsburgh, Sch Med, Dept Neurosurg, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Inst Canc, Brain Tumor Ctr, Pittsburgh, PA 15261 USA

来源：

BRAIN RESEARCH REVIEWS | 1999年 / 29卷 / 2-3期

关键词：

apoptosis; astrocytoma; cell proliferation; farnesyltransferase; geranylgeranyltransferase; glioblastoma multiforme; glioma growth; growth factor; growth inhibition; high-grade glioma; p21-Ras overactivation; mutation; signal transduction;

D O I：

10.1016/S0165-0173(98)00057-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deregulated p21-Ras function, as a result of mutation, overexpression or growth factor-induced overactivation, contributes to at least 30% of human cancer. This article reviews the potential role of the p21-Ras family of GTPases in the regulation of growth of high-grade gliomas and describes how targeting this oncoprotein clinically may provide a novel strategy to counteract glioma proliferation. The application of strategies directed at selectively opposing the deregulated signal transduction pathway of high-grade gliomas may be of potential therapeutic benefit and may offer a whole new arsenal of antineoplastic agents to be included in the multimodal treatment of these challenging neoplasms. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：232 / 249

页数：18

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