Ongoing Clinical Trials in AKI

被引:67
作者
Faubel, Sarah [1 ,2 ]
Chawla, Lakhmir S. [3 ]
Chertow, Glenn M. [4 ]
Goldstein, Stuart L. [5 ]
Jaber, Bertrand L. [6 ]
Liu, Kathleen D. [7 ]
机构
[1] Univ Colorado, Div Nephrol, Denver, CO 80202 USA
[2] Denver Vet Adm Med Ctr, Denver, CO USA
[3] George Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USA
[4] Stanford Univ, Div Nephrol, Palo Alto, CA 94304 USA
[5] Cincinnati Childrens Hosp Med Ctr, Ctr Acute Care Nephrol, Cincinnati, OH USA
[6] St Elizabeths Med Ctr, Kidney & Dialysis Res Lab, Boston, MA USA
[7] Univ Calif San Francisco, Dept Med, Div Nephrol, San Francisco, CA USA
来源
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2012年 / 7卷 / 05期
关键词
ACUTE KIDNEY INJURY; ACUTE-RENAL-FAILURE; CRITICALLY-ILL PATIENTS; LONG-TERM MORTALITY; ACUTE LUNG INJURY; GROWTH-FACTOR-I; HOSPITALIZED-PATIENTS; CARDIAC-SURGERY; CARDIOTHORACIC SURGERY; REPLACEMENT THERAPY;
D O I
10.2215/CJN.12191111
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
AKI is an important public health issue. AKI is a common hospital complication associated with increased in-hospital and long-term mortality, extensive morbidity (including prolonged hospital length of stay), and an estimated annual cost of at least $10 billion in the United States. At present, no specific therapy has been developed to prevent AKI, hasten recovery of kidney function, or abrogate the deleterious systemic effects of AKI. However, recent progress includes establishing a consensus definition of AKI and discovery of novel biomarkers that may allow early detection of AKI. Furthermore, significant insights into the pathophysiology of AKI and its deleterious systemic effects have been gleaned from animal studies. Urgently needed are large, definitive randomized clinical trials testing interventions to prevent and/or treat AKI. This review summarizes and analyzes current ongoing clinical trials registered with clinicaltrials.gov that address prevention or management of AKI. The purpose of this review is to provide a resource for people interested in potential prophylactic and therapeutic approaches to patient care and investigators hoping to plan and execute the next round of randomized clinical trials. Finally, this review discusses research needs that are not addressed by the current clinical trials portfolio and suggests key areas for future research in AKI. Clin J Am Soc Nephrol 7: 861-873, 2012. doi: 10.2215/CJN.12191111
引用
收藏
页码:861 / 873
页数:13
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