Unraveling the mystery surrounding cholesterol's condensing effect

被引：39

作者：

Cao, HH ^{[1
]}

Tokutake, N ^{[1
]}

Regen, SL ^{[1
]}

机构：

[1] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 52期

关键词：

D O I：

10.1021/ja039172x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The results of nearest-neighbor recognition experiments that have been carried out with exchangeable dimers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, in the presence of cholesterol, dihydrocholesterol, coprostanol, cholestane, cholesteryl methy ether, and sitosterol, provide strong support for a condensing mechanism in which the flexible acyl chains of the phospholipids complement, perfectly, the shape of neighboring sterols, thereby leading to a high number of hydrophobic contacts and tight packing. Copyright © 2003 American Chemical Society.

引用

页码：16182 / 16183

页数：2

共 26 条

[1] Cell biology - A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains [J].