A block copolymer for functionalisation of polymersome surfaces

被引：67

作者：

van Dongen, Stijn F. M. ^{[1
]}

Nallani, Madhavan ^{[1
]}

Schoffelen, Sanne ^{[1
]}

Cornelissen, Jeroen J. L. M. ^{[1
]}

Nolte, Roeland J. M. ^{[1
]}

van Hest, Jan C. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 ED Nijmegen, Netherlands

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2008年 / 29卷 / 04期

关键词：

diblock copolymers; enzymes; polymersomes; self-organisation; surface functionalization;

D O I：

10.1002/marc.200700765

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An alpha,omega-diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azido-functionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.

引用

页码：321 / 325

页数：5

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