EJCs at the heart of translational control

被引：99

作者：

Le Hir, Herve ^{[1
,2
,3
]}

Seraphin, Bertrand ^{[1
,2
,3
]}

机构：

[1] CNRS, Euipe lablisee La Ligue, Ctr Genet Mol, UPR 2167, F-91198 Gif Sur Yvette, France

[2] Univ Paris 11, F-91405 Orsay, France

[3] Univ Paris 06, F-75005 Paris, France

来源：

CELL | 2008年 / 133卷 / 02期

关键词：

D O I：

10.1016/j.cell.2008.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, the splicing machinery deposits the exon junction complex (EJC) on mRNA splice junctions. Two studies in this issue now link the EJC to different aspects of translational control. Ma et al. (2008) show that the EJC activates translation downstream of the mTOR signaling pathway, whereas Isken et al. (2008) establish that translation is repressed by partners of the EJC that are implicated in nonsense mediated decay (NMD).

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页码：213 / 216

页数：4

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