Molecular regulation of satellite cell function

被引：99

作者：

Holterman, CE

Rudnicki, MA ^{[1
]}

机构：

[1] Ottawa Hlth Res Inst, Program Mol Med, Ottawa, ON K1H 8L6, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 4-5期

关键词：

skeletal muscle; satellite cell; Pax-7; myogenic regulatory factor; self-renewal;

D O I：

10.1016/j.semcdb.2005.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Quiescent satellite cells are responsible for the repair of post-natal skeletal muscle. These cells are easily identified by their unique morphology within skeletal muscle as well as by several recently elucidated molecular markers. Careful examination of the function of these markers has provided insight into the early events surrounding satellite cell specification and activation. However, the origin of these cells, as well as the mechanisms by which this population is maintained within the adult remain elusive. Furthermore, the ability of non-muscle derived stem cells and the potential multipotency of satellite cells have altered the traditional views of skeletal muscle regeneration. (c) 2005 Published by Elsevier Ltd.

引用

页码：575 / 584

页数：10

共 69 条

[31] Interferon regulatory factor-2 is a transcriptional activator in muscle where it regulates expression of vascular cell adhesion molecule-1 [J].