Homocysteine and methylmalonic acid levels in pregnant Nepali women.: Should cobalamin supplementation be considered?

被引:54
作者
Bondevik, GT
Schneede, J
Refsum, H
Lie, RT
Ulstein, M
Kvåle, G
机构
[1] Univ Bergen, Ctr Int Hlth, N-5021 Bergen, Norway
[2] Univ Bergen, Dept Pharmacol, Bergen, Norway
[3] Univ Bergen, Sect Med Stat, Bergen, Norway
[4] Univ Bergen, Dept Obstet & Gynaecol, Bergen, Norway
关键词
cobalamin; folate; homocysteine; methylmalonic acid; Nepal; pregnancy;
D O I
10.1038/sj.ejcn.1601236
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: The aim of this study was to investigate homocysteine and methylmalonic acid levels as markers of functional cobalamin and folate status in pregnant Nepali women, Design: Cross-sectional study. Setting: Patan Hospital, Kathmandu, Nepal. Subjects: A sub-sample (n = 382) of all pregnant women (n = 2856) coming for their first antenatal visit in a 12 month period, 1994-1995. The selection of the sub-sample was based on maternal haematocrit Values, categorised into three groups: severely, moderately and non-anaemic women. As serum levels of total homocysteine (s-tHcy) and methylmalonic acid (s-MMA) were similar in the three groups, pooled data are presented. Women who had already received micronutrient supplementation (n = 54) were excluded. The remaining women (n = 328) were included in the statistical analysis. Results: Overall mean values (+/- s.d.) of s-tHcy and s-MMA were 9.5 (+/- 4.2) mu mol/l and 0.39 (+/-0.32) mu mol/l, respectively. Elevated s-tHcy (>7.5 mu mol/l) was found in 68% of the women, while 61% had elevated s-MMA (>0.26 mu mol/l). Low s-cobalamin values (<150 pmol/l) were observed in 49% of the women, while only 7% had low s-folate values (<less than or equal to>4.5 nmol/l). s-tHcy was significantly correlated with s-MMA (r=0.28, P<0.001), s-cobalamin (r= -0.30, P<0.001) and s-folate (r= -0.24, P<0.001). s-MMA was significantly associated with s-cobalamin (r= -0.40, P<0.001), but not with s-folate. Conclusions: Functional cobalamin deficiency was very common in the study Population, while functional folate, deficiency was rather uncommon. We suggest considering cobalamin Supplementation to pregnant Nepali women.
引用
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页码:856 / 864
页数:9
相关论文
共 39 条
  • [1] ALLEN LH, 1994, ADV EXP MED BIOL, V352, P173
  • [2] DIAGNOSIS OF COBALAMIN DEFICIENCY .1. USEFULNESS OF SERUM METHYLMALONIC ACID AND TOTAL HOMOCYSTEINE CONCENTRATIONS
    ALLEN, RH
    STABLER, SP
    SAVAGE, DG
    LINDENBAUM, J
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 1990, 34 (02) : 90 - 98
  • [3] ANDERSSON A, 1992, EUR J CLIN CHEM CLIN, V30, P377
  • [4] CAMPYLOBACTER SPECIES AS A CAUSE OF DIARRHEA IN CHILDREN IN CALCUTTA
    BHADRA, RK
    DUTTA, P
    BHATTACHARYA, SK
    DUTTA, SK
    PAL, SC
    NAIR, GB
    [J]. JOURNAL OF INFECTION, 1992, 24 (01) : 55 - 62
  • [5] Seasonal variation in risk of anemia among pregnant Nepali women
    Bondevik, GT
    Lie, RT
    Ulstein, M
    Kvåle, G
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2000, 69 (03) : 215 - 222
  • [6] The prevalence of anemia in pregnant Nepali women -: a study in Kathmandu
    Bondevik, GT
    Ulstein, M
    Lie, RT
    Rana, G
    Kvåle, G
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2000, 79 (05) : 341 - 349
  • [7] Anaemia in pregnancy:: possible causes and risk factors in Nepali women
    Bondevik, GT
    Eskeland, B
    Ulvik, RJ
    Ulstein, M
    Lie, RT
    Schneede, J
    Kvåle, G
    [J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2000, 54 (01) : 3 - 8
  • [8] Plasma homocyst(e)ine concentrations in pregnant and nonpregnant women with controlled folate intake
    Bonnette, RE
    Caudill, MA
    Boddie, AM
    Hutson, AD
    Kauwell, GPA
    Bailey, LB
    [J]. OBSTETRICS AND GYNECOLOGY, 1998, 92 (02) : 167 - 170
  • [9] Brönstrup A, 1998, AM J CLIN NUTR, V68, P1104
  • [10] Brouwer DAJ, 1998, CLIN CHEM, V44, P1545