In vivo and in vitro investigation of photosensitizer-adsorbed superparamagnetic nanoparticles for photodynamic therapy

被引：6

作者：

Park, SI ^{[1
]}

Lim, JH

Kim, JH

Yun, HI

Kim, CO

机构：

[1] Chungnam Natl Univ, Dept Mat Engn, Taejon 305764, South Korea

[2] Chungnam Natl Univ, Div Vet Pharmacol & Toxicol, Taejon 305764, South Korea

[3] Chungnam Natl Univ, Res Ctr Adv Magnet Mat, Taejon 305764, South Korea

来源：

IEEE TRANSACTIONS ON MAGNETICS | 2005年 / 41卷 / 10期

关键词：

cancer cell; in vivo; in vitro; magnetic particle; photodynamic therapy; photosensitizer;

D O I：

10.1109/TMAG.2005.854462

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Superparamagnetic particles of Fe3O4 were nanometrically synthesized by coprecipitation. Hematoporphyrin (HP) and 5-aminole-vulinic acid (ALA) were used as photosensitizers, which were adsorbed on magnetic particles. The adsorption rates of HP and ALA were observed to 2.0% and 12.5% by UV spectrometry and the pico-tag method, respectively. The toxicity of the magnetic fluids was estimated using Sprague-Dawley rats. The photodynamic effect of the photosensitizer-adsorbed magnetic fluids was examined with a human lung cancer cell, for which the light doses were applied to 400 mJ/cm(3).

引用

页码：4111 / 4113

页数：3

共 7 条

[1] Singlet oxygen and superoxide characteristics of a series of novel asymmetric photosensitizers [J].

Haylett, AK ;

McNair, FI ;

McGarvey, D ;

Dodd, NJF ;

Forbes, E ;

Truscott, TG ;

Moore, JV .

CANCER LETTERS, 1997, 112 (02) :233-238

[2] ENDOGENOUS PROTOPORPHYRIN-IX, A CLINICALLY USEFUL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY [J].

KENNEDY, JC ;

POTTIER, RH .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1992, 14 (04) :275-292

[3] PHOTODYNAMIC THERAPY WITH ENDOGENOUS PROTOPORPHYRIN .9. BASIC PRINCIPLES AND PRESENT CLINICAL-EXPERIENCE [J].

KENNEDY, JC ;

POTTIER, RH ;

PROSS, DC .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1990, 6 (1-2) :143-148

[4] Adhesion of photosensitizer to ferrofluids for use in photodynamic therapy [J].

Kim, JH ;

Kwon, SK ;

Kim, CO .

NANOTECHNOLOGY, 2002, 13 (05) :610-614

[5] Effects of surfactant on properties of magnetic fluids for biomedical application [J].

Park, SI ;

Lim, JH ;

Yun, HI ;

Roh, JS ;

Kim, CG ;

Kim, CO .

PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS, 2004, 241 (07) :1662-1664

[6] Preparation of photosensitizer-coated magnetic fluid for treatment of tumor [J].

Park, SI ;

Kim, J ;

Kim, CO .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2004, 272 :2340-2342

[7] Functional magnetic particles for medical application [J].

Shinkai, M .

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2002, 94 (06) :606-613

← 1 →