Electroretinographic effects of an intravitreal injection of triamcinolone in rabbit retina

被引:37
作者
Dierks, D
Lei, B
Zhang, KQ
Hainsworth, DP
机构
[1] Univ Missouri, Mason Eye Inst, Columbia, MO 65212 USA
[2] Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Columbia, MO 65212 USA
关键词
D O I
10.1001/archopht.123.11.1563
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To investigate the clinical, histologic, and electroretinographic effects of intravitreal injection of triamcinolone acetonide suspension in the rabbit retina. Methods: Three groups of 6 rabbits each received intravitreal injections. Group I received 4 mg of triamcinolone acetonide, group 2 received an equal volume (0.1 mL) of the corticosteroid supernatant, and group 3 received 4 mg of triamcinolone acetonide with the supernatant replaced with balanced salt solution. Uninjected left eyes served as controls. Electroretinograms were obtained at baseline and at 3 to 4 and 6 to 7 days after injection of triamcinolone. Enucleated eyes were examined histologically. Results: Ocular examination revealed no differences among the 3 groups. When subjected to stimulation with moderate to high flash intensities, eyes that had received intravitreal injections of triamcinolone (groups 1 and 3) had a 10% to 25% increase in dark-adapted a- and b-wave electroretinographic amplitudes. No histologic differences were observed between injected and control eyes. Conclusions: Intravitreal injection of 4 mg of triamcinolone acetonide does not cause a toxic reaction in the rabbit retina after 7 days. Triamcinolone therapy may augment the rod-driven electroretinographic responses, suggesting a mechanism by which visual function may improve. Clinical Relevance: Evaluation of the toxic effects of triamcinolone is useful because of increased applications of intravitreal injection.
引用
收藏
页码:1563 / 1569
页数:7
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