Chromosome 12 and late-onset Alzheimer's disease

被引：24

作者：

Poduslo, SE ^{[1
]}

Yin, X ^{[1
]}

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Div Neurol, Lubbock, TX 79430 USA

来源：

NEUROSCIENCE LETTERS | 2001年 / 310卷 / 2-3期

关键词：

Alzheimer's disease; chromosome; 12;

D O I：

10.1016/S0304-3940(01)02130-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. Using large extended families with multiple affected, we found that three markers on chromosome 12 were linked with late-onset Alzheimer's disease. These markers were downstream from the gene for alpha-2 macroglobulin. It is likely that multiple genes will be identified either as risk factors or as causative agents for late-onset Alzheimer's disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：188 / 190

页数：3

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