Mediterranean dietary pattern and cancer risk in the EPIC cohort

被引：199

作者：

Couto, E. ^{[1
,2
]}

Boffetta, P. ^{[1
,3
,4
]}

Lagiou, P. ^{[5
]}

Ferrari, P. ^{[6
]}

Buckland, G. ^{[7
]}

Overvad, K. ^{[8
]}

Dahm, C. C. ^{[9
]}

Tjonneland, A. ^{[10
]}

Olsen, A. ^{[10
]}

Clavel-Chapelon, F. ^{[11
,12
]}

Boutron-Ruault, M-C ^{[11
,12
]}

Cottet, V. ^{[11
,12
]}

Trichopoulos, D. ^{[4
,13
,14
]}

Naska, A. ^{[5
]}

Benetou, V. ^{[5
]}

Kaaks, R. ^{[15
]}

Rohrmann, S. ^{[15
]}

Boeing, H. ^{[16
]}

von Ruesten, A. ^{[16
]}

Panico, S. ^{[17
]}

Pala, V. ^{[18
]}

Vineis, P. ^{[19
,20
]}

Palli, D. ^{[21
]}

Tumino, R. ^{[22
,23
]}

May, A. ^{[24
]}

Peeters, P. H. ^{[24
]}

Bueno-de-Mesquita, H. B. ^{[25
,26
]}

Buchner, F. L. ^{[25
,27
]}

Lund, E. ^{[28
]}

Skeie, G. ^{[28
]}

Engeset, D. ^{[28
]}

Gonzalez, C. A. ^{[7
]}

Navarro, C. ^{[29
,30
]}

Rodriguez, L. ^{[31
]}

Sanchez, M-J ^{[29
,32
]}

Amiano, P. ^{[29
,33
]}

Barricarte, A. ^{[29
,34
]}

Hallmans, G. ^{[35
]}

Johansson, I. ^{[36
]}

Manjer, J. ^{[37
]}

Wirfart, E. ^{[38
]}

Allen, N. E. ^{[39
]}

Crowe, F. ^{[39
]}

Khaw, K-T ^{[40
]}

Wareham, N. ^{[40
]}

Moskal, A. ^{[1
]}

Slimani, N. ^{[1
]}

Jenab, M. ^{[1
]}

Romaguera, D. ^{[19
]}

Mouw, T. ^{[19
]}

机构：

[1] Int Agcy Res Canc, F-69372 Lyon, France

[2] Univ Oslo, Dept Nutr, Oslo, Norway

[3] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY 10029 USA

[4] Hellen Hlth Fdn, Athens, Greece

[5] Univ Athens, Sch Med, Dept Hyg Epidemiol & med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[6] European Food Safety, Data Collect & Exposure Unit, Parma, Italy

[7] Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[8] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[9] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[10] Danish Canc Soc, Inst Canc Epidemiol, Dept Diet Canc & Hlth, Copenhagen, Denmark

[11] Inst Gustave Roussy, INSERM, U1018, Ctr Res Epidemiol & Populat Hlth, F-94805 Villejuif, France

[12] Paris S Univ, UMRS 1018, F-94805 Villejuif, France

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Acad Athens, Bur Epidemiol Res, Athens, Greece

[15] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[16] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[17] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[18] Fdn IRCSS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[19] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[20] Inst Sci Interchange Fdn, Dept Epidemiol & Life Sci, Turin, Italy

[21] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[22] ASP 7, Canc Registry, Ragusa, Italy

[23] ASP 7, Histopathol Unit, Ragusa, Italy

[24] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[25] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[26] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[27] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands

[28] Univ Tromso, Dept Community Med, Tromso, Norway

[29] CIBER Epidemiol & Salud Publ, Consortium Biomed Res Epidemiol & Publ Hlth, Barcelona, Spain

[30] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[31] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[32] Andalusian Sch Publ Hlth, Granada Canc Registry, Granada, Spain

[33] Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[34] Publ Hlth Inst Navarra, Serv Epidemiol Prevent & Hlth Promot, Pamplona, Spain

[35] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[36] Umea Univ, Dept Odontol, Umea, Sweden

[37] Lund Univ, Skane Univ Hosp, Dept Surg, Malmo, Sweden

[38] Lund Univ, Dept Clin Sci Malmo Nutr Epidemiol, Malmo, Sweden

[39] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[40] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

来源：

BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Mediterranean diet; dietary patterns; cancer risk; epidemiology; BREAST-CANCER; ADHERENCE; MORTALITY; SURVIVAL; POPULATION; CONFORMITY; ALCOHOL;

D O I：

10.1038/bjc.2011.106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

BACKGROUND: Although several studies have investigated the association of the Mediterranean diet with overall mortality or risk of specific cancers, data on overall cancer risk are sparse. METHODS: We examined the association between adherence to Mediterranean dietary pattern and overall cancer risk using data from the European Prospective Investigation Into Cancer and nutrition, a multi-centre prospective cohort study including 142 605 men and 335 873. Adherence to Mediterranean diet was examined using a score (range: 0-9) considering the combined intake of fruits and nuts, vegetables, legumes, cereals, lipids, fish, dairy products, meat products, and alcohol. Association with cancer incidence was assessed through Cox regression modelling, controlling for potential confounders. RESULTS: In all, 9669 incident cancers in men and 21 062 in women were identified. A lower overall cancer risk was found among individuals with greater adherence to Mediterranean diet (hazard ratio = 0.96, 95% CI 0.95-0.98) for a two-point increment of the Mediterranean diet score. The apparent inverse association was stronger for smoking-related cancers than for cancers not known to be related to tobacco (P (heterogeneity) = 0.008). In all, 4.7% of cancers among men and 2.4% in women would be avoided in this population if study subjects had a greater adherence to Mediterranean dietary pattern. CONCLUSION: Greater adherence to a Mediterranean dietary pattern could reduce overall cancer risk. British Journal of Cancer (2011) 104, 1493-1499. doi:10.1038/bjc.2011.106 www.bjcancer.com Published online 5 April 2011 (C) 2011 Cancer Research UK

引用

页码：1493 / 1499

页数：7

共 33 条

[1]

Trends in food availability determined by the Food and Agriculture Organization's food balance sheets in Mediterranean Europe in comparison with other European areas [J].

Balanza, Rafael ;

Garcia-Lorda, Pilar ;

Perez-Rodrigo, Carmen ;

Aranceta, Javier ;

Bonet, Monica Bullo ;

Salas-Salvado, Jordi .

PUBLIC HEALTH NUTRITION, 2007, 10 (02) :168-176

[2]

Conformity to traditional Mediterranean diet and cancer incidence: the Greek EPIC cohort [J].

Benetou, V. ;

Trichopoulou, A. ;

Orfanos, P. ;

Naska, A. ;

Lagiou, P. ;

Boffetta, P. ;

Trichopoulos, D. .

BRITISH JOURNAL OF CANCER, 2008, 99 (01) :191-195

[3]

Bergström A, 2001, INT J CANCER, V91, P421, DOI 10.1002/1097-0215(200002)9999:9999<::AID-IJC1053>3.0.CO

[4]

2-T

[5]

The burden of cancer attributable to alcohol drinking [J].

Boffetta, Paolo ;

Hashibe, Mia ;

La Vecchia, Carlo ;

Zatonski, Witold ;

Rehm, Juergen .

INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (04) :884-887

[6]

Bosetti C, 2003, CANCER EPIDEM BIOMAR, V12, P1091

[7]

Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study [J].

Buckland, Genevieve ;

Agudo, Antonio ;

Lujan, Leila ;

Jakszyn, Paula ;

Bueno-de-Mesquita, H. Bas ;

Palli, Domenico ;

Boeing, Heiner ;

Carneiro, Fatima ;

Krogh, Vittorio ;

Sacerdote, Carlotta ;

Tumino, Rosario ;

Panico, Salvatore ;

Nesi, Gabriella ;

Manjer, Jonas ;

Regner, Sara ;

Johansson, Ingegerd ;

Stenling, Roger ;

Sanchez, Maria-Jose ;

Dorronsoro, Miren ;

Barricarte, Aurelio ;

Navarro, Carmen ;

Ramon Quiros, J. ;

Allen, Naomi E. ;

Key, Timothy J. ;

Bingham, Sheila ;

Kaaks, Rudolf ;

Overvad, Kim ;

Jensen, Majken ;

Olsen, Anja ;

Tjonneland, Anne ;

Peeters, Petra H. M. ;

Numans, Mattijs E. ;

Ocke, Marga C. ;

Clavel-Chapelon, Francoise ;

Morois, Sophie ;

Boutron-Ruault, Marie-Christine ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Lund, Eiliv ;

Couto, Elisabeth ;

Boffeta, Paolo ;

Jenab, Mazda ;

Riboli, Elio ;

Romaguera, Dora ;

Mouw, Traci ;

Gonzalez, Carlos A. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (02) :381-390

[8]

Constance P, 1990, INT CLASSIFICATION D

[9]

Postmenopausal Breast Cancer Risk and Dietary Patterns in the E3N-EPIC Prospective Cohort Study [J].

Cottet, Vanessa ;

Touvier, Mathilde ;

Fournier, Agnes ;

Touillaud, Marina S. ;

Lafay, Lionel ;

Clavel-Chapelon, Francoise ;

Boutron-Ruault, Marie-Christine .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2009, 170 (10) :1257-1267

[10]

Adherence to the USDA food guide, DASH eating plan, and Mediterranean dietary pattern reduces risk of colorectal adenoma [J].

Dixon, L. Beth ;

Subar, Amy F. ;

Peters, Ulrike ;

Weissfeld, Joel L. ;

Bresalier, Robert S. ;

Risch, Adam ;

Schatzkin, Arthur ;

Hayes, Richard B. .

JOURNAL OF NUTRITION, 2007, 137 (11) :2443-2450

← 1 2 3 4 →