TAR-DNA binding protein-43 and alterations in the hippocampus

被引：24

作者：

Rauramaa, Tuomas ^{[2
,3
]}

Pikkarainen, Maria ^{[4
]}

Englund, Elisabet ^{[5
]}

Ince, Paul G. ^{[6
]}

Jellinger, Kurt ^{[7
]}

Paetau, Anders ^{[8
]}

Alafuzoff, Irina ^{[1
,2
,4
]}

机构：

[1] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, Univ Uppsala Hosp, S-75185 Uppsala, Sweden

[2] Kuopio Univ Hosp, Dept Pathol, SF-70210 Kuopio, Finland

[3] Univ Eastern Finland, Inst Clin Med, Unit Pathol, Kuopio, Finland

[4] Univ Eastern Finland, Inst Clin Med, Neurol Unit, Sect Neuropathol, Kuopio, Finland

[5] Univ Lund Hosp, Dept Pathol, S-22185 Lund, Sweden

[6] Univ Sheffield, Dept Neurosci, Sheffield, S Yorkshire, England

[7] Inst Clin Neurobiol, Vienna, Austria

[8] Univ Helsinki, Dept Pathol, Helsinki, Finland

来源：

JOURNAL OF NEURAL TRANSMISSION | 2011年 / 118卷 / 05期

关键词：

TAR-DNA binding protein-43; Hyperphosphorylated-tau; p62; Immunohistochemistry; Post-mortem; Hippocampal alterations; FRONTOTEMPORAL LOBAR DEGENERATION; AMYOTROPHIC-LATERAL-SCLEROSIS; ARGYROPHILIC GRAIN DISEASE; ALPHA-SYNUCLEIN PATHOLOGY; ALZHEIMERS-DISEASE; LEWY BODIES; NEUROFIBRILLARY PATHOLOGY; TDP-43; IMMUNOREACTIVITY; PHOSPHORYLATED TDP-43; UBIQUITIN;

D O I：

10.1007/s00702-010-0574-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.

引用

页码：683 / 689

页数：7

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