Biotransformation of ethinylestradiol by microalgae

被引：80

作者：

Della Greca, M. ^{[1
]}

Pinto, G. ^{[2
]}

Pistillo, P. ^{[1
]}

Pollio, A. ^{[2
]}

Previtera, L. ^{[1
]}

Temussi, F. ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Organ & Biochim, UDR Napoli 4 Consorzio INCA, I-80126 Naples, Italy

[2] Univ Naples Federico II, Sez Biol Vegetale, Dipartimento Sci Biol, I-80139 Naples, Italy

来源：

CHEMOSPHERE | 2008年 / 70卷 / 11期

关键词：

Selenastrum capricornutum; Scenedesmus quadricauda; Ankistrodesmus braunii; glucosylation; hydroxylation;

D O I：

10.1016/j.chemosphere.2007.09.011

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The capability of biotransformation of 11 microalgae strains was tested on ethinylestradiol (EE). Seven strains were ineffective whilst Selenastrum capricornutum, Scenedesmus quadricauda, Scenedesmus vacuolatus and Ankistrodesmus braunii biotransformed the substrate. EE was converted by S. capricornutum in three products (ethinylestradiol glucoside, 3-beta-D-glucopyranosyl-2-hydroxyethinylestradiol, and 3-beta-D-glucopyranosyl-6 beta-hydroxyethinyl estradiol) in 40%, 5%, and 5% yields, respectively. S. quadricauda transformed EE into 17 alpha-ethinyl-1,4-estradien-10,17p-diol-3-one (12%) and A. braunii transformed EE into 6-alpha-hydroxy-ethinylestradiol (25%). It is noteworthy that EE is converted in 92% yield in ethinylestradiol glucoside by S. capricornutum when using optimal algal density conditions. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2047 / 2053

页数：7

共 26 条

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