Activated leukocyte cell adhesion molecule: a new paradox in cancer

被引：102

作者：

Ofori-Acquah, Solomon F.

King, Judy A. ^{[1
]}

机构：

[1] Univ S Alabama, Dept Pharmacol, Ctr Lung Biol, Mobile, AL 36688 USA

来源：

TRANSLATIONAL RESEARCH | 2008年 / 151卷 / 03期

关键词：

D O I：

10.1016/j.trsl.2007.09.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The activated leukocyte cell adhesion molecule (ALCAM/CD166/melanoma metastasis clone D (MEMD)) is an immunoglobulin superfamily cell adhesion molecule. It is expressed developmentally in cells of all 3 embryonic lineages. The ALCAM expression is limited to subsets of cells in most adult tissues. ALCAM is localized at intercellular junctions in epithelium presumably as part of the adhesive complex that maintains tissue architecture. Over the past decade, alterations in expression of ALCAM have been reported in several human tumors (melanoma, prostate cancer, breast cancer, colorectal carcinoma, bladder cancer, and esophageal squamous cell carcinoma). This review summarizes the current knowledge of the role of ALCAM in malignancies.

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页码：122 / 128

页数：7

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