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Mucins in cancer: Protection and control of the cell surface

被引：1420
作者：
Hollingsworth, MA [1 ]
Swanson, BJ [1 ]
机构：
[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA
来源：
NATURE REVIEWS CANCER | 2004年 / 4卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc1251
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mucins - large extracellular proteins that are heavily glycosylated with complex oligosaccharides - establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.
引用
收藏
页码：45 / 60
页数：16
相关论文
共 194 条
  • [1] IMMUNOGENICITY OF SYNTHETIC TF-KLH (KEYHOLE LIMPET HEMOCYANIN) AND STN-KLH CONJUGATES IN COLORECTAL-CARCINOMA PATIENTS
    ADLURI, S
    HELLING, F
    OGATA, S
    ZHANG, SL
    ITZKOWITZ, SH
    LLOYD, KO
    LIVINGSTON, PO
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 1995, 41 (03) : 185 - 192
  • [2] Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
    Agrawal, B
    Krantz, MJ
    Reddish, MA
    Longenecker, BM
    [J]. NATURE MEDICINE, 1998, 4 (01) : 43 - 49
  • [3] The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy
    Agrawal, B
    Gendler, SJ
    Longenecker, BM
    [J]. MOLECULAR MEDICINE TODAY, 1998, 4 (09): : 397 - 403
  • [4] Agrawal B, 1998, CANCER RES, V58, P4079
  • [5] Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2 mucin
    Asker, N
    Axelsson, MAB
    Olofsson, SO
    Hansson, GC
    [J]. BIOCHEMICAL JOURNAL, 1998, 335 : 381 - 387
  • [6] Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus
    Asker, N
    Axelsson, MAB
    Olofsson, SO
    Hansson, GC
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (30) : 18857 - 18863
  • [7] BALLOUL JM, 1994, CELL MOL BIOL, V40, P49
  • [8] BANFI G, 1993, CLIN CHEM, V39, P420
  • [9] CA 19.9, CA 242 and CEA in the diagnosis and follow-up of pancreatic cancer
    Banfi, G
    Bravi, S
    Ardemagni, A
    Zerbi, A
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 1996, 11 (02) : 77 - 81
  • [10] REACTIVITY OF A MONOCLONAL-ANTIBODY WITH HUMAN OVARIAN-CARCINOMA
    BAST, RC
    FEENEY, M
    LAZARUS, H
    NADLER, LM
    COLVIN, RB
    KNAPP, RC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (05) : 1331 - 1337
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