Mucins in cancer: Protection and control of the cell surface

被引：1420

作者：

Hollingsworth, MA ^{[1
]}

Swanson, BJ ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1251

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mucins - large extracellular proteins that are heavily glycosylated with complex oligosaccharides - establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.

引用

页码：45 / 60

页数：16

共 194 条

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