The ESCRT Pathway

被引：1148

作者：

Henne, William M. ^{[1
,2
]}

Buchkovich, Nicholas J. ^{[1
,2
]}

Emr, Scott D. ^{[1
,2
]}

机构：

[1] Cornell Univ, Weill Inst Cell & Mol Biol, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

DEVELOPMENTAL CELL | 2011年 / 21卷 / 01期

关键词：

RECEPTOR DOWN-REGULATION; DOA4 DEUBIQUITINATING ENZYME; MULTIVESICULAR BODY PATHWAY; UBIQUITIN-INTERACTING MOTIF; ENDOSOME-ASSOCIATED COMPLEX; MEMBRANE CURVATURE; SORTING COMPLEX; SACCHAROMYCES-CEREVISIAE; STRUCTURAL BASIS; ENDOPLASMIC-RETICULUM;

D O I：

10.1016/j.devcel.2011.05.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspectives: (1) the ESCRT proteins themselves, (2) the cargo they sort, and (3) the membrane they deform. Here, we review ESCRT function from these perspectives and discuss how ESCRTs may drive vesicle budding.

引用

页码：77 / 91

页数：15

共 151 条

[31] Requirement for microtubules in new membrane formation during cytokinesis of Xenopus embryos
Danilchik, MV
Funk, WC
Brown, EE
Larkin, K
[J]. DEVELOPMENTAL BIOLOGY, 1998, 194 (01) : 47 - 60
[32] Mechanisms of Endocytosis
Doherty, Gary J.
McMahon, Harvey T.
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 : 857 - 902
[33] A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes
Dukes, Joseph D.
Richardson, Judith D.
Simmons, Ruth
Whitley, Paul
[J]. BIOCHEMICAL JOURNAL, 2008, 411 : 233 - 239
[34] Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding
Eastman, SW
Martin-Serrano, J
Chung, W
Zang, T
Bieniasz, PD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (01) : 628 - 636
[35] Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission
Elia, Natalie
Sougrat, Rachid
Spurlin, Tighe A.
Hurley, James H.
Lippincott-Schwartz, Jennifer
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) : 4846 - 4851
[36] Computational Model of Membrane Fission Catalyzed by ESCRT-III
Fabrikant, Gur
Lata, Suman
Riches, James D.
Briggs, John A. G.
Weissenhorn, Winfried
Kozlov, Michael M.
[J]. PLOS COMPUTATIONAL BIOLOGY, 2009, 5 (11)
[37] Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
Filimonenko, Maria
Stuffers, Susanne
Raiborg, Camilla
Yamamoto, Ai
Malerod, Lene
Fisher, Elizabeth M. C.
Isaacs, Adrian
Brech, Andreas
Stenmark, Harald
Simonsen, Anne
[J]. JOURNAL OF CELL BIOLOGY, 2007, 179 (03) : 485 - 500
[38] Structure and ubiquitin binding of the ubiquitin-interacting motif
Fisher, RD
Wang, B
Alam, SL
Higginson, DS
Robinson, H
Sundquist, WI
Hill, CP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (31) : 28976 - 28984
[39] BAR domains and membrane curvature: bringing your curves to the BAR
Gallop, JL
McMahon, HT
[J]. LIPIDS, RAFTS AND TRAFFIC, 2005, 72 : 223 - 231
[40] Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus, JE
von Schwedler, UK
Pornillos, OW
Morham, SG
Zavitz, KH
Wang, HE
Wettstein, DA
Stray, KM
Côté, M
Rich, RL
Myszka, DG
Sundquist, WI
[J]. CELL, 2001, 107 (01) : 55 - 65

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