Subharmonic generation from ultrasonic contrast agents

被引:65
作者
Krishna, PD [1 ]
Shankar, PM [1 ]
Newhouse, VL [1 ]
机构
[1] Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USA
关键词
D O I
10.1088/0031-9155/44/3/004
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Ultrasonic contrast agents are used to enhance backscatter from blood and thus aid in delineating blood from surrounding tissue. However, behaviour of contrast agents in an acoustic field is nonlinear and leads to harmonic components in the backscattered signal. Various research groups have investigated second-harmonic emissions. In this work, the subharmonic emission from contrast agents is investigated with a view towards potential use in imaging. It is shown that the microbubbles with various surface properties, such as contrast agents, generate significant subharmonics under various insonating conditions. Theoretical results as well as experimental results using Optison(TM) indicate the generation of strong subharmonics with burst insonation at twice the resonant frequency of the microbubble. It is suggested that subharmonic imaging may provide a better modality than second-harmonic imaging to delineate blood from tissue and will be of significant importance for imaging deep vessels, such as in echocardiography and vascular diseases, due to the high signal-to-clutter ratio of the subharmonic imaging.
引用
收藏
页码:681 / 694
页数:14
相关论文
共 31 条
[11]  
Forsberg F, 1997, INT J IMAG SYST TECH, V8, P69, DOI 10.1002/(SICI)1098-1098(1997)8:1<69::AID-IMA9>3.0.CO
[12]  
2-R
[13]   On the feasibility of real time, in vivo harmonic imaging with proteinaceous microspheres [J].
Forsberg, F ;
Goldberg, BB ;
Liu, JB ;
Merton, DA ;
Rawool, NM .
JOURNAL OF ULTRASOUND IN MEDICINE, 1996, 15 (12) :853-860
[14]   GALACTOSE-BASED INTRAVENOUS SONOGRAPHIC CONTRAST AGENT - EXPERIMENTAL STUDIES [J].
GOLDBERG, BB ;
LIU, JB ;
BURNS, PN ;
MERTON, DA .
JOURNAL OF ULTRASOUND IN MEDICINE, 1993, 12 (08) :463-470
[15]  
Gramiak R, 1968, Invest Radiol, V3, P356
[16]   Second harmonic characteristics of the ultrasound contrast agents Albunex and FSO69 [J].
Krishna, PD ;
Newhouse, VL .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1997, 23 (03) :453-459
[17]   NUMERICAL INVESTIGATION OF NONLINEAR OSCILLATIONS OF GAS-BUBBLES IN LIQUIDS [J].
LAUTERBORN, W .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1976, 59 (02) :283-293
[18]  
Leighton T. G., 1994, ACOUSTIC BUBBLE
[19]   Experimental observation of subharmonic oscillations in Infoson bubbles [J].
Lotsberg, O ;
Hovem, JM ;
Aksum, B .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1996, 99 (03) :1366-1369
[20]   COUNTING BUBBLES ACOUSTICALLY - REVIEW [J].
MEDWIN, H .
ULTRASONICS, 1977, 15 (01) :7-13