Challenges in drug discovery for novel antifilarials

被引:26
作者
Townson, Simon [2 ]
Ramirez, Bernadette [1 ]
Fakorede, Foluke [1 ]
Mouries, Marie-Annick [1 ]
Nwaka, Solomon [1 ]
机构
[1] WHO, Special Programme Res & Training Trop Dis TDR, CH-1211 Geneva 27, Switzerland
[2] Northwick Pk Inst Med Res, Trop Parasit Dis Unit, Harrow HA1 3UJ, Middx, England
关键词
antifilarial drug discovery; compound screening; Helminth Drug Initiative; lymphatic filariasis; onchocerciasis;
D O I
10.1517/17460441.2.S1.S63
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Control programmes are at present focused on the elimination of onchocerciasis and lymphatic filariasis as public health problems in countries where they are endemic. The availability of effective drugs used in combination (diethylcarbamazine, albendazole and ivermectin) has paved the way for the implementation of Mass Drug Administration (MDA) campaigns. Considerable progress in the implementation of MDA programmes had led to significant reductions in transmission and morbidity. However, new drugs are needed to overcome the threat of resistance to existing microfilaricides as well as to identify new macrofilaricides. This paper discusses the existing screening tools available for antifilarial drug discovery and efforts towards optimising their use through the Helminth Drug Initiative.
引用
收藏
页码:S63 / S73
页数:11
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