Concise and practical synthesis of latrunculin A by ring-closing enyne-yne metathesis

被引:181
作者
Fürstner, A [1 ]
Turet, L [1 ]
机构
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
关键词
alkynes; cross-coupling; macrocycles; metathesis; natural products;
D O I
10.1002/anie.200500390
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Chemical Equation Presented) Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C-C bond-formation reactions, including a ring-closing enyne-yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码:3462 / 3466
页数:5
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