Altered uric acid levels and disease states

被引:262
作者
Kutzing, Melinda K. [1 ,2 ]
Firestein, Bonnie L. [1 ]
机构
[1] Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ 08855 USA
[2] Rutgers State Univ, Grad Program Biomed Engn, Piscataway, NJ USA
关键词
D O I
10.1124/jpet.107.129031
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Altered serum uric acid concentrations, both above and below normal levels, have been linked to a number of disease states. An abnormally high uric acid level has been correlated with gout, hypertension, cardiovascular disease, and renal disease, whereas a reduced uric acid concentration has been linked to multiple sclerosis, Parkinson's disease, Alzheimer's disease, and optic neuritis. Historically, uric acid has been considered a marker of these disease states. Recent studies, however, have provided evidence that uric acid may actually play a role in the development or progression of such diseases. As a result, the manipulation of uric acid concentrations is now either included in, or being investigated for, the treatment of a variety of disease states.
引用
收藏
页码:1 / 7
页数:7
相关论文
共 69 条
[1]   Childhood uric acid predicts adult blood pressure - The Bogalusa Heart Study [J].
Alper, AB ;
Chen, W ;
Yau, L ;
Srinivasan, SR ;
Berenson, GS ;
Hamm, LL .
HYPERTENSION, 2005, 45 (01) :34-38
[2]   URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].
AMES, BN ;
CATHCART, R ;
SCHWIERS, E ;
HOCHSTEIN, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862
[3]  
[Anonymous], 2000, BRIT J CLIN PHARMACO
[4]   New insights into renal transport of urate [J].
Anzai, Naohiko ;
Kanai, Yoshikatsu ;
Endou, Hitoshi .
CURRENT OPINION IN RHEUMATOLOGY, 2007, 19 (02) :151-157
[5]   Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis [J].
Bagasra, O ;
Michaels, FH ;
Zheng, YM ;
Bobroski, LE ;
Spitsin, SV ;
Fu, ZF ;
Tawadros, R ;
Koprowski, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) :12041-12045
[6]   Oxidative damage and tyrosine nitration from peroxynitrite [J].
Beckman, JS .
CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (05) :836-844
[7]   RENAL-FUNCTION IN GOUT .4. ANALYSIS OF 524 GOUTY SUBJECTS INCLUDING LONG-TERM FOLLOW-UP STUDIES [J].
BERGER, L ;
YU, TF .
AMERICAN JOURNAL OF MEDICINE, 1975, 59 (05) :605-613
[8]   Uric acid is a risk factor for myocardial infarction and stroke - The Rotterdam Study [J].
Bos, Michiel J. ;
Koudstaal, Peter J. ;
Hofman, Albert ;
Witteman, Jacqueline C. M. ;
Breteler, Monique M. B. .
STROKE, 2006, 37 (06) :1503-1507
[9]   Pathogenesis of gout [J].
Choi, HK ;
Mount, DB ;
Reginato, AM .
ANNALS OF INTERNAL MEDICINE, 2005, 143 (07) :499-516
[10]   URIC-ACID IS REDUCED IN THE SUBSTANTIA-NIGRA IN PARKINSONS-DISEASE - EFFECT ON DOPAMINE OXIDATION [J].
CHURCH, WH ;
WARD, VL .
BRAIN RESEARCH BULLETIN, 1994, 33 (04) :419-425