A single amino acid substitution in the ICP27 protein of herpes simplex virus type 1 is responsible for its resistance to leptomycin B

被引：18

作者：

Murata, T ^{[1
]}

Goshima, F ^{[1
]}

Koshizuka, T ^{[1
]}

Takakuwa, H ^{[1
]}

Nishiyama, Y ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Dis Mechanism & Control Res Inst, Virol Lab,Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 02期

关键词：

D O I：

10.1128/JVI.75.2.1039-1043.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequences revealed that a single amino acid substitution within the ICP27 gene is responsible for conferring this resistance.

引用

收藏

页码：1039 / 1043

页数：5

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共 40 条

[21] EVALUATION OF COLOCALIZATION INTERACTIONS BETWEEN THE IE110, IE175, AND IE63 TRANSACTIVATOR PROTEINS OF HERPES-SIMPLEX VIRUS WITHIN SUBCELLULAR PUNCTATE STRUCTURES [J].

MULLEN, MA ;

GERSTBERGER, S ;

CIUFO, DM ;

MOSCA, JD ;

HAYWARD, GS .

JOURNAL OF VIROLOGY, 1995, 69 (01) :476-491

[22] Mitochondrial distribution and function in herpes simplex virus-infected cells [J].

Murata, T ;

Goshima, F ;

Daikoku, T ;

Inagaki-Ohara, K ;

Takakuwa, H ;

Kato, K ;

Nishiyama, Y .

JOURNAL OF GENERAL VIROLOGY, 2000, 81 :401-406

[23] CRM1 mediates nuclear export of nonstructural protein 2 from parvovirus minute virus of mice [J].

Ohshima, T ;

Nakajima, T ;

Oishi, T ;

Imamoto, N ;

Yoneda, Y ;

Fukamizu, A ;

Yagami, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 264 (01) :144-150

[24] INHIBITION OF HERPES-SIMPLEX VIRUS REPLICATION BY PHOSPHONOACETIC ACID [J].

OVERBY, LR ;

ROBISHAW, EE ;

SCHLEICHER, JB ;

RUETER, A ;

SHIPKOWITZ, NL ;

MAO, JCH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1974, 6 (03) :360-365

[25] Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27 [J].

Panagiotidis, CA ;

Lium, EK ;

Silverstein, SJ .

JOURNAL OF VIROLOGY, 1997, 71 (02) :1547-1557

[26] Posttranscriptional regulation in herpes simplex virus [J].

Phelan, A ;

Clements, JB .

SEMINARS IN VIROLOGY, 1998, 8 (04) :309-318

[27] A HERPES-SIMPLEX VIRUS TYPE-1 IMMEDIATE-EARLY GENE-PRODUCT, IE63, REGULATES SMALL NUCLEAR RIBONUCLEOPROTEIN DISTRIBUTION [J].

PHELAN, A ;

CARMOFONSECA, M ;

MCLAUCHLAN, J ;

LAMOND, AI ;

CLEMENTS, JB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :9056-9060

[28] Herpes simplex virus type 1 protein IE63 affects the nuclear export of virus intron-containing transcripts [J].

Phelan, A ;

Dunlop, J ;

Clements, JB .

JOURNAL OF VIROLOGY, 1996, 70 (08) :5255-5265

[29] Herpes simplex virus type 1 immediate early protein IE63 shuttles between nuclear compartments and the cytoplasm [J].

Phelan, A ;

Clements, JB .

JOURNAL OF GENERAL VIROLOGY, 1997, 78 :3327-3331

[30] SHUTTLING OF PRE-MESSENGER-RNA BINDING-PROTEINS BETWEEN NUCLEUS AND CYTOPLASM [J].

PINOLROMA, S ;

DREYFUSS, G .

NATURE, 1992, 355 (6362) :730-732

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