Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis

被引：52

作者：

Hallock, YF ^{[1
]}

Cardellina, JH ^{[1
]}

Schäffer, M ^{[1
]}

Bringmann, G ^{[1
]}

François, G ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] Natl Canc Inst, Lab Drug Discovery Res & Dev, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(98)00304-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; rr! vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum. Published by Elsevier Science Ltd.

引用

页码：1729 / 1734

页数：6

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