Epidemiology of neurodegeneration

被引:368
作者
Mayeux, R [1 ]
机构
[1] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA
关键词
Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; incidence; prevalence; risk factors; genetic risk;
D O I
10.1146/annurev.neuro.26.043002.094919
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alzheimer's disease, Parkinson's disease, and motor neuron disease share a propensity to occur with increasing age and as either a sporadic or a familial disorder. A number of behavioral and environmental risk factors have been proposed for each disorder, but most associations lack consistency and specificity. Over the last decade the remarkable frequency of these disorders has become apparent, and the identification of mutations in genes has provided the means to understand their pathogenesis. Better and more accurate means to characterize and diagnose these diseases has greatly facilitated analytic epidemiology. The analysis of behavioral and genetic factors that may lower disease risk has led to clinical trials that are either in progress or being planned with the aim of preventing these disorders.
引用
收藏
页码:81 / 104
页数:24
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