Glycine transporters:: crucial roles of pharmacological interest revealed by gene deletion

被引：88

作者：

Aragón, C ^{[1
]}

López-Corcuera, B ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Ctr Biol Mol Severo Ochoa, CSIC, Madrid 28049, Spain

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 06期

关键词：

D O I：

10.1016/j.tips.2005.04.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The functions of the high-affinity glycine transporters (GLYTs) in vivo have been revealed recently using gene-deletion studies. Results from studies of homozygous knockout mice have reinforced the idea that GLYTs might be specific clinical targets to modulate inhibitory glycine-mediated neurotransmission. In addition, molecular and behavioural analysis of heterozygous mice has confirmed the therapeutic potential of GLYT1 inhibitors in the treatment of several neurological and psychiatric disorders.

引用

页码：283 / 286

页数：4

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