Microwave-enhanced aromatic dehalogenation studies: a rapid deuterium-labelling procedure

被引：38

作者：

Jones, JR ^{[1
]}

Lockley, WJS

Lu, SY

Thompson, SP

机构：

[1] Univ Surrey, Dept Chem, Guildford GU2 7XH, Surrey, England

[2] AstraZeneca R&D Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)01941-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rapid (<1 min) and specific deuterium labelling is achieved through the microwave-enhanced dehalogenation of a number of N-4-picolyl-4-halogenobenzamides using deuterated formate as solid deuterium donor and either homogeneous or heterogeneous catalysts; the percentage deuterium incorporation is a function of the kind of solvent used. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：331 / 332

页数：2

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