The Gel Electrophoresis Markup Language (GelML) from the Proteomics Standards Initiative

被引:14
作者
Gibson, Frank [1 ]
Hoogland, Christine [2 ]
Martinez-Bartolome, Salvador [3 ]
Alberto Medina-Aunon, J. [3 ]
Pablo Albar, Juan [3 ]
Babnigg, Gyorgy [4 ]
Wipat, Anil [1 ]
Hermjakob, Henning [5 ]
Almeida, Jonas S. [6 ]
Stanislaus, Romesh [6 ]
Paton, Norman W. [7 ]
Jones, Andrew R. [8 ]
机构
[1] Newcastle Univ, Sch Comp Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Swiss Inst Bioinformat, Proteome Informat Grp, Geneva, Switzerland
[3] CSIC, CNB, Prote Facil, Madrid, Spain
[4] Argonne Natl Lab, Biosci Div, Argonne, IL 60439 USA
[5] European Bioinformat Inst, European Mol Biol Lab, Cambridge, England
[6] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA
[7] Univ Manchester, Sch Comp Sci, Manchester, Lancs, England
[8] Univ Liverpool, Dept Comparat Mol Med, Sch Vet Sci, Liverpool L69 7ZJ, Merseyside, England
基金
英国生物技术与生命科学研究理事会;
关键词
Bioinformatics; Database; Data standard; Gel electrophoresis; Ontology; FUNCTIONAL GENOMICS; MINIMUM INFORMATION; MASS-SPECTROMETRY; PUBLIC REPOSITORY; DATA MODEL; GUIDELINES; FUGE; PROTEIN;
D O I
10.1002/pmic.201000120
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The Human Proteome Organisation's Proteomics Standards Initiative has developed the GelML (gel electrophoresis markup language) data exchange format for representing gel electrophoresis experiments performed in proteomics investigations. The format closely follows the reporting guidelines for gel electrophoresis, which are part of the Minimum Information About a Proteomics Experiment (MIAPE) set of modules. GelML supports the capture of metadata (such as experimental protocols) and data (such as gel images) resulting from gel electrophoresis so that laboratories can be compliant with the MIAPE Gel Electrophoresis guidelines, while allowing such data sets to be exchanged or downloaded from public repositories. The format is sufficiently flexible to capture data from a broad range of experimental processes, and complements other PSI formats for MS data and the results of protein and peptide identifications to capture entire gel-based proteome workflows. GelML has resulted from the open standardisation process of PSI consisting of both public consultation and anonymous review of the specifications.
引用
收藏
页码:3073 / 3081
页数:9
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