Efficient synthesis of α-galactosyl ceramide analogues using glycosyl iodide donors

被引:105
作者
Du, WJ [1 ]
Gervay-Hague, J [1 ]
机构
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
关键词
D O I
10.1021/ol050659f
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to a GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.
引用
收藏
页码:2063 / 2065
页数:3
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