Histamine H3 Receptor as a Drug Discovery Target

被引：139

作者：

Berlin, Michael ^{[1
]}

Boyce, Christopher W. ^{[1
]}

Ruiz, Manuel de Lera ^{[1
]}

机构：

[1] Merck Res Labs, Chem Res, Kenilworth, NJ 07033 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 01期

关键词：

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; CORTICAL ACETYLCHOLINE-RELEASE; PIG PERFUSED BRONCHIOLES; IN-VIVO; PHARMACOLOGICAL CHARACTERIZATION; SUBSTANCE-P; H-3-RECEPTOR ANTAGONIST; COGNITIVE PERFORMANCE; MEDICINAL CHEMISTRY; H3; RECEPTOR;

D O I：

10.1021/jm100064d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：26 / 53

页数：28

共 286 条

[1] Cerebral ischemia and brain histamine [J].

Adachi, N .

BRAIN RESEARCH REVIEWS, 2005, 50 (02) :275-286

[2] Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons [J].

Agnati, LF ;

Ferré, S ;

Lluis, C ;

Franco, R ;

Fuxe, K .

PHARMACOLOGICAL REVIEWS, 2003, 55 (03) :509-550

[3] Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice [J].

Akhtar, Mohd ;

Devi, P. Uma ;

Ali, Atif ;

Pillai, K. K. ;

Vohora, Divya .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2006, 20 (04) :373-378

[4] Design, synthesis, and structure-activity relationships of acetylene-based histamine H3 receptor antagonists [J].

Ali, SM ;

Tedford, CE ;

Gregory, R ;

Handley, MK ;

Yates, SL ;

Hirth, WW ;

Phillips, JG .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (05) :903-909

[5] Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists [J].

Altenbach, Robert J. ;

Liu, Huaqing ;

Banfor, Patricia N. ;

Brownian, Kaitlin E. ;

Fox, Gerard B. ;

Fryer, Ryan M. ;

Komater, Victoria A. ;

Krueger, Kathleen M. ;

Marsh, Kennan ;

Miller, Thomas R. ;

Pan, Jia Bao ;

Pan, Liping ;

Sun, Minghua ;

Thiffault, Christine ;

Wetter, Jill ;

Zhao, Chen ;

Zhou, Deliang ;

Esbenshade, Timothy A. ;

Hancock, Arthur A. ;

Cowart, Marlon D. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (22) :5439-5448

[6] The role of histamine on cognition [J].

Alvarez, Edgardo O. .

BEHAVIOURAL BRAIN RESEARCH, 2009, 199 (02) :183-189

[7]

[Anonymous], 1970, BMJ-BRIT MED J, V1, P614

[8]

[Anonymous], 1968, JAMA, V203, P1122

[9]

[Anonymous], 2005, PRINCIPLES PRACTICE

[10]

[Anonymous], INV DRUGS DAT IDDB

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