Genotypic characterization of clarithromycin-resistant and -: Susceptible Helicobacter pylori strains from the same patient demonstrates existence of two unrelated isolates

被引：16

作者：

Wang, G ^{[1
]}

Jiang, Q ^{[1
]}

Taylor, DE ^{[1
]}

机构：

[1] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7, Canada

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1998年 / 36卷 / 09期

关键词：

D O I：

10.1128/JCM.36.9.2730-2731.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Clarithromycin-susceptible and clarithromycin-resistant Helicobacter pylori isolates from the same patient were investigated far the mode of development and mechanism of clarithromycin resistance. The clarithromycin-resistant strain UA1182 harbors homozygous A-to-G mutations at position 2143 in both copies of the 23S rRNA gene and has a phenotype of resistance to clarithromycin and clindamycin best no significant resistance to streptogramin B. Pulsed-field gel electrophoresis patterns of NruI- and NotI-digested genomic DNA from the Cla(s) and Cla(r) isolates demonstrated that they are genetically distinct, suggesting that the development of clarithromycin resistance is not from the mutation of the existing Clas strain but from a completely new strain.

引用

页码：2730 / 2731

页数：2

共 21 条

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