Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring

被引：56

作者：

Lifson, Mark A. ^{[1
]}

Ozen, Mehmet Ozgun ^{[1
]}

Inci, Fatih ^{[1
]}

Wang, ShuQi ^{[1
,2
,3
,4
]}

Inan, Hakan ^{[1
,5
]}

Baday, Murat ^{[1
]}

Henrich, Timothy J. ^{[6
]}

Demirci, Utkan ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Demirci Bioacoust MEMS Med BAMM Lab, Radiol Dept,Canary Ctr Stanford Canc Early Detect, Palo Alto, CA 94304 USA

[2] Zhejiang Univ, Coll Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Zhejiang, Peoples R China

[3] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China

[4] Zhejiang Univ, Inst Translat Med, Hangzhou, Zhejiang, Peoples R China

[5] Zirve Univ, Fac Med, Gaziantep, Turkey

[6] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 103卷

关键词：

HIV-1/AIDS; Point-of-care; Emerging technologies; Nanotechnology; Microfluidics; IMMUNODEFICIENCY-VIRUS TYPE-1; LABEL-FREE DETECTION; QUARTZ-CRYSTAL MICROBALANCE; VIRAL LOAD; LATENT RESERVOIR; QUANTITATIVE DETECTION; ENVELOPE GLYCOPROTEIN; MAGNETIC-LEVITATION; DNA BIOSENSOR; INJECT DRUGS;

D O I：

10.1016/j.addr.2016.05.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

HIV-1 is a major global epidemic that requires sophisticated clinical management. There have been remarkable efforts to develop new strategies for detecting and treating HIV-1, as it has been challenging to translate them into resource-limited settings. Significant research efforts have been recently devoted to developing point-of-care (POC) diagnostics that can monitor HIV-1 viral load with high sensitivity by leveraging micro- and nano scale technologies. These POC devices can be applied to monitoring of antiretroviral therapy, during mother-to-child transmission, and identification of latent HIV-1 reservoirs. In this review, we discuss current challenges in HIV-1 diagnosis and therapy in resource-limited settings and present emerging technologies that aim to address these challenges using innovative solutions. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：90 / 104

页数：15

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