Novel Flavaglines Displaying Improved Cytotoxicity

被引：50

作者：

Thuaud, Frederic ^{[1
]}

Ribeiro, Nigel ^{[1
]}

Gaiddon, Christian ^{[2
]}

Cresteil, Thierry ^{[3
]}

Desaubry, Laurent ^{[1
]}

机构：

[1] Univ Strasbourg, Dept Med Chem, Fac Pharm, CNRS,Therapeut Innovat Lab UMR 7200, F-67401 Illkirch Graffenstaden, France

[2] Univ Strasbourg, Fac Med, INSERM, Lab Signalisat & Neurodegeneresence UMRS692, F-67085 Strasbourg, France

[3] CNRS, Inst Chim Subst Nat UPR 2301, F-91198 Gif Sur Yvette, France

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 01期

关键词：

ROCAGLAMIDE DERIVATIVES; AGLAIA-ELLIPTICA; LIGNANS; CELLS; APOPTOSIS; GROWTH;

D O I：

10.1021/jm101318b

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel flavagline analogues were synthesized and examined with respect to their cytotoxicity Structural features critical to the potential of this class of anticancer natural products wet e unraveled We demonstrated, in particular, that the introduction of substituants at C-2 has a deleterious effect on multidrug resistance Replacement of the hydroxy at C-1 by an aminoformyl with the opposite configuration enhances the cytotoxicity and led to a compound that reduces tumors growth in an allograft model at nontoxic doses

引用

页码：411 / 415

页数：5

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