Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata

被引：35

作者：

Chumkaew, Parinuch

Kato, Shigeru

Chantrapromma, Kan ^{[1
]}

机构：

[1] Walailak Univ, Sch Sci, Nakhon Si Thammarat 80160, Thailand

[2] Walailak Univ, Res Unit Nat Prod Utilizat, Nakhon Si Thammarat 80160, Thailand

[3] Seikei Univ, Fac Engn, Dept Appl Chem, Tokyo 1808633, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 09期

关键词：

Amoora cucullata; Meliaceae; rocaglamide derivative; cytotoxicity;

D O I：

10.1248/cpb.54.1344

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3 '-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3 '-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures were elucidated by spectroscopic methods. Compounds 1-3, 6, and 7 exhibited potent cytotoxicity against KB, BC, and NCI-H187 cell lines, whereas 4 and 5 showed selective cytotoxicity against NCI-HI87 cell line.

引用

页码：1344 / 1346

页数：3

共 12 条

[1]

Boonyapraphat N., 1998, THAI MED PLANTS, VII, P157

[2] Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada [J].

Chaidir ;

Lin, WH ;

Ebel, R ;

Edrada, R ;

Wray, V ;

Nimtz, M ;

Sumaryono, W ;

Proksch, P .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (09) :1216-1220

[3] A new triterpenoid ester from the fruits of Bruguiera parviflora [J].

Chumkaew, P ;

Kato, S ;

Chantrapromma, K .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (01) :95-96

[4] Antimycobacterial activity of phorbol esters from the fruits of Sapium indicum [J].

Chumkaew, P ;

Karalai, C ;

Ponglimanont, C ;

Chantrapromma, K .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (04) :540-543

[5] New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla [J].

Dreyer, M ;

Nugroho, BW ;

Bohnenstengel, FI ;

Ebel, R ;

Wray, V ;

Witte, L ;

Bringmann, G ;

Mühlbacher, J ;

Herold, M ;

Hung, PD ;

Kiet, LC ;

Proksch, P .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (04) :415-420

[6] INSECTICIDAL 1H-CYCLOPENTATETRAHYDRO[B]BENZOFURANS FROM AGLAIA-ODORATA [J].

ISHIBASHI, F ;

SATASOOK, C ;

ISMAN, MB ;

TOWERS, GHN .

PHYTOCHEMISTRY, 1993, 32 (02) :307-310

[7] TRADITIONAL MEDICINAL-PLANTS OF THAILAND .20. CYTOTOXIC AND ANTIMALARIAL BISBENZYLISOQUINOLINE ALKALOIDS FROM STEPHANIA-ERECTA [J].

LIKHITWITAYAWUID, K ;

ANGERHOFER, CK ;

CORDELL, GA ;

PEZZUTO, JM ;

RUANGRUNGSI, N .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01) :30-38

[8] Dammarane triterpenes from the hypocotyls and fruits of Ceriops tagal [J].

Pakhathirathien, C ;

Karalai, C ;

Ponglimanont, C ;

Subhadhirasakul, S ;

Chantrapromma, K .

JOURNAL OF NATURAL PRODUCTS, 2005, 68 (12) :1787-1789

[9] Cytotoxic constituents of the twigs and leaves of Aglaia rubiginosa [J].

Rivero-Cruz, JF ;

Chai, HB ;

Kardono, LBS ;

Setyowati, FM ;

Afriatini, JJ ;

Riswan, S ;

Farnsworth, NR ;

Cordell, GA ;

Pezzuto, JM ;

Swanson, SM ;

Kinghorn, AD .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (03) :343-347

[10] Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae) [J].

Schneider, C ;

Bohnenstengel, FI ;

Nugroho, BW ;

Wray, V ;

Witte, L ;

Hung, PD ;

Kiet, LC ;

Proksch, P .

PHYTOCHEMISTRY, 2000, 54 (08) :731-736

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