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Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae)

被引：45
作者：
Schneider, C
Bohnenstengel, FI
Nugroho, BW
Wray, V
Witte, L
Hung, PD
Kiet, LC
Proksch, P
机构：
[1] Univ Dusseldorf, Inst Pharmazeut Biol, D-40225 Dusseldorf, Germany
[2] Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany
[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmazeut Biol, D-38106 Braunschweig, Germany
[4] Vietnam Natl Univ, Coll Nat Sci, Dept Chem, Ho Chi Minh, Vietnam
[5] Vietnam Natl Univ, Coll Nat Sci, Dept Bot, Ho Chi Minh, Vietnam
[6] Bogor Agr Univ, Dept Plant Pests & Dis, Fac Agr, Bogor 16144, Indonesia
来源：
PHYTOCHEMISTRY | 2000年 / 54卷 / 08期
关键词：
Aglaia spectabilis; Meliaceae; benzofurans; rocaglamide derivatives; structure elucidation; natural insecticides; Spodoptera littoralis;
D O I：
10.1016/S0031-9422(00)00205-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bark of Aglaia spectabilis collected on the island of Phu Quoc (Vietnam) yielded 11 insecticidal cyclopentatetrahydrobenzofurans of the rocaglamide type including four new natural products. Structure elucidation of the new compounds is described. All rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet. LC50 values varied from 0.8 to 80 ppm. The most active compounds isolated, methylrocaglate and C-3' hydroxylmethylrocaglate, were similar with regard to their insecticidal activity to the well-known natural insecticide azadirachtin. (C) 2000 Elsevier Science Ltd. All rights reserved.
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收藏
页码：731 / 736
页数：6
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