Insecticidal rocaglamide derivatives from Aglaia elliptica and A-harmsiana

被引：42

作者：

Nugroho, BW

Gussregen, B

Wray, V

Witte, L

Bringmann, G

Proksch, P

机构：

[1] UNIV WURZBURG, LEHRSTUHL PHARMAZEUT BIOL, JULIUS VON SACHS INST BIOWISSENSCHAFTEN, D-97082 WURZBURG, GERMANY

[2] GESELL BIOTECHNOL FORSCH MBH, D-38124 BRAUNSCHWEIG, GERMANY

[3] TECH UNIV CAROLO WILHELMINA BRAUNSCHWEIG, INST PHARMAZEUT BIOL, D-38106 BRAUNSCHWEIG, GERMANY

[4] UNIV WURZBURG, INST ORGAN CHEM, D-97074 WURZBURG, GERMANY

[5] BOGOR AGR UNIV, FAC AGR, DEPT PLANT PESTS & DIS, BOGOR 16144, INDONESIA

来源：

PHYTOCHEMISTRY | 1997年 / 45卷 / 08期

关键词：

Aglaia elliptica; A-harmsiana; Meliaceae; rocaglamide derivatives; structure elucidation; natural insecticides; Spodoptera littoralis;

D O I：

10.1016/S0031-9422(97)00253-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fruits of Aglaia elliptica and leaves of A. harmsiana yielded seven insecticidal rocaglamide derivatives including five components which proved to be new natural products. Structure elucidation of the new compounds is described. All rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet with LC50 values varying from 0.8-19.7 ppm. The known didesmethylrocaglamide was the most active compound encountered. Its LC50 (0.8 ppm) and EC50 (0.05 ppm) were identical to those of azadirachtin which was included as a positive control. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：1579 / 1585

页数：7

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