Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation

被引：201

作者：

Curtin, Caroline M. ^{[1
,2
]}

Cunniffe, Grainne M. ^{[2
]}

Lyons, Frank G. ^{[1
]}

Bessho, Kazuhisa ^{[3
]}

Dickson, Glenn R. ^{[4
]}

Duffy, Garry P. ^{[1
,2
]}

O'Brien, Fergal J. ^{[1
,2
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Anat, Dublin 2, Ireland

[2] Trinity Coll Dublin, Trinity Ctr Bioengn, Dublin, Ireland

[3] Kyoto Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, Kyoto 6068501, Japan

[4] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Canc Res & Cell Biol, Belfast BT7 1NN, Antrim, North Ireland

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 06期

基金：

爱尔兰科学基金会; 欧洲研究理事会;

关键词：

biomedical applications; biomineralization; bionanotechnology; tissue engineering; composite materials; MORPHOGENETIC PROTEIN-2; GAG SCAFFOLDS; ADENOVIRAL VECTOR; THERAPY; MODEL; DNA;

D O I：

10.1002/adma.201103828

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.

引用

页码：749 / +

页数：7

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