Effector memory αβ T lymphocytes can express FcγRIIIa and mediate antibody-dependent cellular cytotoxicity

被引:48
作者
Clemenceau, Beatrice [1 ,2 ]
Vivien, Regine [1 ,2 ]
Berthome, Mathilde [1 ,2 ]
Robillard, Nelly [3 ]
Garand, Richard [3 ]
Gallot, Geraldine [1 ,2 ]
Vollant, Solene [1 ,2 ]
Vie, Henri [1 ,2 ]
机构
[1] INSERM, U601, F-44093 Nantes, France
[2] Univ Nantes, Nantes, France
[3] CHU Nantes, Hematol Lab, F-44035 Nantes 01, France
关键词
D O I
10.4049/jimmunol.180.8.5327
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human memory T cells are comprised of distinct populations with different homing potential and effector functions: central memory T cells that mount recall responses to Ags in secondary lymphoid organs, and effector memory T cells that confer immediate protection in peripheral tissues. In the present study we demonstrate that a proportion of effector memory T cells express Fc gamma RIIIa (CD16), are perforin positive, and directly mediate Ab-dependent cytotoxicity ex vivo. This particular alpha beta T lymphocyte subset has the morphology of large granular lymphocytes, increases proportionately in vivo during reactive lymphocytosis, and can be detected in vitro among EBV-specific T lymphocytes after stimulation with EBV Ags. Consequently, during a normal immune response, amplification of these effector memory T lymphocytes that are capable of Ab-dependent cytotoxicity may have beneficial or harmful consequences depending on the presence of pathogen- or tissue-specific Abs, respectively.
引用
收藏
页码:5327 / 5334
页数:8
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