A case of intractable epilepsy positive for the detection of measles virus genome in the cerebrospinal fluid and peripheral mononuclear cells using reverse transcriptase-polymerase chain reaction

被引：20

作者：

Kawashima, H ^{[1
]}

Miyajima, T ^{[1
]}

Mori, T ^{[1
]}

Yuan, LP ^{[1
]}

Ogihara, M ^{[1
]}

Kinoue, K ^{[1
]}

Takekuma, K ^{[1
]}

Hoshika, A ^{[1
]}

机构：

[1] KITASATO INST,DEPT VIROL,TOKYO 108,JAPAN

来源：

BRAIN & DEVELOPMENT | 1996年 / 18卷 / 03期

关键词：

mental deterioration; measles; Epilepsy; H gene; SSPE; Rasmussen syndrome;

D O I：

10.1016/0387-7604(95)00154-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a rare case of intractable frontal lobe epilepsy with mental deterioration, in which the measles virus gene was detected from the cerebrospinal fluid (CSF) and peripheral mononuclear cells (PBMC) obtained 9 years after the first epileptic episode using reverse transcriptase-polymerase chain reaction (RT-PCR). The patient had been immunized with air attenuated measles vaccine and had no history of clinically apparent acute measles infection. However the analysis of the sequence of the PCR product from CSF showed the circulating wild strain genotype at the time when the patient complained of his first epileptic episode.

引用

页码：220 / 223

页数：4

共 13 条

[1] SUBACUTE SCLEROSING PANENCEPHALITIS IN AN INFANT - DIAGNOSTIC ROLE OF VIRAL GENOME ANALYSIS [J].