Localization of soluble guanylyl cyclase α-subunit in identified insect neurons

被引：20

作者：

Elphick, MR ^{[1
]}

Jones, IW ^{[1
]}

机构：

[1] Univ London Queen Mary & Westfield Coll, Sch Biol Sci, London E1 4NS, England

来源：

BRAIN RESEARCH | 1998年 / 800卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

soluble guanylyl cyclase; cyclic-GMP; Schistocerca gregaria; locust; nitric oxide;

D O I：

10.1016/S0006-8993(98)00522-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of soluble guanylyl cyclase in the brain of the locust Schistocerca gregaria was analysed using antisera to a highly conserved region (X-peptide) of the Drosophila soluble guanylyl cyclase alpha-subunit (SGC alpha). Analysis of locust brain and locust eye homogenates in Western blots using X-peptide antisera revealed specific staining of a similar to 65 kDa band, which is similar to the expected molecular mass for a SGC alpha-subunit. SGC alpha-immunoreactivity was localize in identified neuronal components of several sensory systems including photoreceptors of the compound eyes and ocelli, large ocellar interneurons, antennal mechanosensory neurons and olfactory interneurons. These neurons are putative targets for the gas nitric oxide which activates guanylyl cyclase activity in the locust brain. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：174 / 179

页数：6

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