Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking

被引：132

作者：

Braeckmans, Kevin ^{[1
]}

Buyens, Kevin ^{[1
]}

Bouquet, Wim ^{[2
]}

Vervaet, Chris ^{[2
]}

Joye, Philippe ^{[3
]}

De Vos, Filip ^{[3
]}

Plawinski, Laurent ^{[4
]}

Doeuvre, Loic ^{[4
]}

Angles-Cano, Eduardo ^{[4
]}

Sanders, Niek N. ^{[5
]}

Demeester, Jo ^{[1
]}

De Smedt, Stefaan C. ^{[1
]}

机构：

[1] Univ Ghent, Lab Gen Biochem & Phys Pharm, B-9000 Ghent, Belgium

[2] Univ Ghent, Pharmaceut Technol Lab, B-9000 Ghent, Belgium

[3] Univ Ghent, Lab Radiopharm, B-9000 Ghent, Belgium

[4] GIP Cyceron, CNRS, INSERM U919, UMR 6232, F-14074 Caen, France

[5] Univ Ghent, Lab Gene Therapy, B-9820 Merelbeke, Belgium

来源：

NANO LETTERS | 2010年 / 10卷 / 11期

关键词：

Nanobiophotonics; nanoparticles; drug delivery; nanomedicines; medical diagnostics; POLY(ETHYLENE GLYCOL); DELIVERY; LIPOSOMES; MICROPARTICLES; DYNAMICS; CELLS; DRUG; SIZE;

D O I：

10.1021/nl103264u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Accurate sizing of nanoparticles in biological media is important for drug delivery and biomedical imaging applications since size directly influences the nanoparticle processing and nanotoxicity in vivo. Using fluorescence single particle cracking we have succeeded for the first time in following the aggregation of drug delivery nanoparticles in real time in undiluted whole blood. We demonstrate that, by using a suitable surface functionalization, nanoparticle aggregation in the blood circulation is prevented to a large extent.

引用

页码：4435 / 4442

页数：8

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